Prostate Cancer

The prostate is a gland situated in the male reproductive system, and its found bellow the bladder, in front of the rectum. It surrounds the part of the urethra just bellow the bladder, the tube that empties the bladder, and produces a fluid which forms a part of the content of the semen. Prostate cancer is that type of cancer that forms in the tissues of the prostate, and usually the older man presents prostate cancer.

Many causes of the prostate cancer are yet unknown or misunderstood. But there are some factors which are related with the prostate cancer. Some of these factors are often by the medical nature or because of the genes, such age, family history of prostate cancer, family history of breast cancer, origins, diets and others. Other factors are too much drinking alcohol or caffeine, or any abuse. Not only those factors are known, yet those are the most important.

Ketoconazole is a synthetic antifungal agent used to treat prostate cancer since 1970. When it’ given at traditional doses of to treat prostate cancer, it was noted to temporarily decrease of the level of testosterone and adrenal androgen. Higher doses are producing a bigger wall for hormones. The high concentration of ketoconazole appears to be the reason for bigger walls. Ketoconazole has so many miracles effects against both prostate cancers that it is surprising not to see this agent as a mainstay in the initial treatment of prostate cancer. Ketoconazole rapidly lowers serum testosterone to castrate levels in several hours by mechanisms that are different by agonists and antiandrogens.

Ketoconazole:is an agent which suppresses adrenal androgen synthesis and hence deprive cells of androgens, but also has direct cytotoxic activity against prostate cancer cells. Ketoconazole has exhibited significant activity in patients with advanced prostate cancer. However, overall and cardiac-specific toxicity was reported to be high Patients with prostate cancer, definite of androgen-independence varying, but usually include a documented castrate level of testosterone and failure of second-line hormonal therapy. One second-line therapy is ketoconazole, a broad-spectrum azole anti-fungal drug that inhibits gonad and adrenal steroid synthesis. So this is an important medicine, used successfully in the treatment of prostate cancer higher androstenedione levels predict likelihood of response to ketoconazole and improved survival compared with patients with lower levels.

This data suggest that therapy with ketoconazole is less effective in patients with low levels of androgen at baseline than those with testosterone. Almost all prostate cancer tumors treated by androgen deprivation eventually achieve the ability to grow and progress in the absence of androgens. These are known as hormone-refractory prostate cancer The prognosis for prostate cancer disease is generally poor; however, there are a number of second-line treatments that may delay the worsening of symptoms.

Prostate Cancer | Prostate Cancer Research Institute |